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J Res Health Sci. 2020;20(3): e00486.
doi: 10.34172/jrhs.2020.18
PMID: 33169718
PMCID: PMC7585767
Scopus ID: 85092170776
  Abstract View: 612
  PDF Download: 233
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Original Article

Dietary Total Antioxidant Capacity and Risk of Non-Alcoholic Fatty Liver Disease: A Case‐Control Study

Ammar Salehi-Sahlabadi, Amin Mokari, Maryam Elhamkia, Fariba Farahmand, Masoumeh Jabbari, Azita Hekmatdost*
*Corresponding Author: Email: ammar.salehi.nut@gmail.com

Abstract

Background: Dietary total antioxidant capacity (DTAC) has been proposed as a tool for assessing the intake of antioxidants. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of NAFLD.

Study design: A case-control study.

Methods: In this age‐and sex‐matched case‐control study in 2019, patients with NAFLD and healthy controls were recruited from a hospital clinic. All participants completed a validated 168‐item food frequency questionnaire, the results of which were subsequently used to generate dietary TAC. Oxygen radical absorbance capacity values were used to calculate dietary TAC.

Results: Altogether, 225 patients with NAFLD and 450 healthy controls were enrolled. Participants with NAFLD had a higher mean weight, BMI, energy (P<0.050), and lower physical activity and DTAC scores (P<0.050) than the control group. In an adjusted model, participants who were in the highest quartile of dietary TAC had a lower risk of NAFLD (odds ratio 0.78, 95% CI: 0.67, 0.91).

Conclusion: A high DTAC was related to a decreased risk of NAFLD. Suggest the intake of a diet with high antioxidant capacity is significant at preventing NAFLD. Increasingly itemized investigations in design of randomized control trials require to reveal more insight into these results.

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Submitted: 13 Feb 2020
Revision: 05 Oct 2020
ePublished: 30 Jul 2020
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