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J Res Health Sci. 2014;14(3): 218-220.
PMID: 25209910
Scopus ID: 84924865179
  Abstract View: 89
  PDF Download: 24

Original Article

The L-selectin Phe206Leu gene polymorphism is not associated with visceral leishmaniasis

Khosro Sardarian*, Mohammad Abasi, Ghasem Solgi, Mehrdad Hajilooi
*Corresponding Author: Email: khsardarian@gmail.com

Abstract

Background: Previous studies revealed that selectins play key roles in homing of immune cells to inflamed tissues and lymphatic organs. L-selectins are expressed on immune cells and interact with P and E selectins to homing to the tissues, hence, the polymorphisms within the gene of L-selectins may are associated with alteration in its expression. Thus, the current cross-sectional analytical study has been designed to investigate the polymorphisms within L-selectin gene and their relation with visceral leishmaniasis (VL).

Methods: This study was performed on 194 samples during 2004-2012.The PCR-SSP and immunoflorescence techniques were used to evaluate the L-selectins polymorphism and anti-Leishmania antibody titration, respectively, in 56, 74 and 64 seropositive VL patients (group 1), seropositive healthy controls (group 2) and seronegative healthy controls (group 3).

Results: The results showed that the genotypes (P=0.711) and alleles (P=0.679) within L-selectins gene (A/C) was not differ between groups. Our results also demonstrated that the genotypes within L-selectins in group 1 (P=0.807) and 2 (P=0.441) were not associated with the titration of anti-leishmania antibody.

Conclusions: The results identified that the polymorphisms within L-selectins gene were not associated with VL and it may be concluded that these genotypes and alleles are unable to affect immune responses in VL patients.

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Submitted: 17 Apr 2014
Revision: 31 May 2014
ePublished: 31 May 2014
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