L-Carnitine Level in Seminal Plasma of Fertile and Infertile Men

N Sheikh, MT Goodarzi, H Bab Al-Havaejee, MR Safari, I Amiri, R Najafi, J Hadeie


Background: To determine any correlation between infertility and semen quality with concentrations of L-carnitine in human seminal plasma.

Methods: This case-control study performed in Fatemieh Hospital in Hamadan, Iran. Seminal plasma of 72 infertile men and 80 men with proved fertility as a control group was investigated and L-carnitine level was determined using UV enzymatic test at 340 nm.

Results: The concentration of L-carnitine was significantly lower in the infertile group compared with control group (80.59±56.43 mg/l versus 108.43±42.26 mg/l; P= 0.0009). There was also a statistically significant positive correlation between seminal plasma L-carnitine concentration, total sperm count, and the percentage of motile sperm (P= 0.0009, and P= 0.0000, respectively).

Conclusion: These finding suggest that the determination of seminal plasma L-carnitine level may be a useful test in evaluation of male infertility.


Sperm motility, Sperm Count, Infertility, Male, Carnitine, Semen

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