Dietary Total Antioxidant Capacity and Risk of Non-Alcoholic Fatty Liver Disease: A Case‐Control Study

Ammar Salehi-Sahlabadi, Amin Mokari, Maryam Elhamkia, Fariba Farahmand, Masoumeh Jabbari, Azita Hekmatdost


Background: Dietary total antioxidant capacity (DTAC) has been proposed as a tool for assessing the intake of antioxidants. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of NAFLD.

Study design: A case-control study.

Methods: In this age‐and sex‐matched case‐control study in 2019, patients with NAFLD and healthy controls were recruited from a hospital clinic. All participants completed a validated 168‐item food frequency questionnaire, the results of which were subsequently used to generate dietary TAC. Oxygen radical absorbance capacity values were used to calculate dietary TAC.

Results: Altogether, 225 patients with NAFLD and 450 healthy controls were enrolled. Participants with NAFLD had a higher mean weight, BMI, energy (P<0.050), and lower physical activity and DTAC scores (P<0.050) than the control group. In an adjusted model, participants who were in the highest quartile of dietary TAC had a lower risk of NAFLD (odds ratio 0.78, 95% CI: 0.67, 0.91).

Conclusion: A high DTAC was related to a decreased risk of NAFLD. Suggest the intake of a diet with high antioxidant capacity is significant at preventing NAFLD. Increasingly itemized investigations in design of randomized control trials require to reveal more insight into these results.


Non-alcoholic fatty liver disease; Diet; Case-control studies

Full Text: PDF

JRHS Office:

School of Public Health, Hamadan University of Medical Sciences, Shaheed Fahmideh Ave. Hamadan, Islamic Republic of Iran

Postal code: 6517838695, PO box: 65175-4171

Tel: +98 81 38380292, Fax: +98 81 38380509