Modeling Time to Blindness of Glaucoma Patients: A Case Study at Jimma University Medical Center

Meskerem Getachew Gebremariam, Reta Habtamu Bacha, Demeke Kifle Demissie, Kibrealem Sisay Wolde, Kenenisa Tadesse Dame, Geremew Muleta Akessa

Abstract


Background: Glaucoma is a significant public health problem due to its substantial increase in the projected number of glaucoma cases. In Ethiopia, glaucoma accounts for 5.2% of irreversible blindness and is the fifth main cause of blindness. The main objective of this study was to modeling time to blindness of left and right eyes of glaucoma patients.

Study Design: An institution-based retrospective cohort study.

Methods: This study was conducted among 315 glaucoma patients admitted to the Ophthalmology Department of Jimma University Medical Center, Southwest Ethiopia, from January 1, 2016, to August 30, 2020. Kaplan-Meier survival analysis and semiparametric and parametric copula models were applied to identify factors that affect time to the blindness in glaucoma patients and the dependence between time to the blindness of the left and right eyes, respectively. An Akaike information criterion was used to select the best non-nested model.

Results: In total, 211 (66.9%) out of 315 glaucoma patients were blind, whereas 104 (33.1%) patients were censored. The median time to the blindness of the left and right eyes was determined to be 12 months. The result suggested that the risk of the blindness in male patients was 1.005 (P=0.01) times higher than that in female patients, and the risk of the blindness in patients who had early, moderate, and advanced glaucoma was estimated to be 0.582 (P=0.002), 0.485 (P=0.001) and 0.887 (P=0.003) times less than that in the patients with absolute glaucoma, respectively.

Conclusions: Age, place of residence, gender, type of medication, diabetes disease, stage of glaucoma, duration of treatment, Intraocular Pressure, and cup-disk ratio were significantly associated with and affected by the time to the blindness of left and right eyes in glaucoma patients. Awareness should be given to the community to reduce the burden of glaucoma.


Keywords


Archimedean copula families; Ethiopia; Glaucoma; Kendall’s tau; Time to blindness



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