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J Res Health Sci. 2022;22(4): e00565.
doi: 10.34172/jrhs.2022.100
PMID: 37571936
PMCID: PMC10422163
Scopus ID: 85167773529
  Abstract View: 839
  PDF Download: 283
  Full Text View: 196

Original Article

Effects of Hypertension Alone and in Comorbidity with Diabetes on Death within 30 Days among Inpatients with COVID-19 Infection

Erfan Ayubi 1, Fatemeh Torkaman Asadi 2,3, Shiva Borzouei 4, Behnaz Alafchi 5, Mobin Faghih Soleimani 6, Saman Khosronejad 6, Salman Khazaei 7,8, Seyed Saman Talebi 4*

1 Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Infectious Disease, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3 Infectious Disease Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
4 Department of Internal Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
5 Modeling Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
6 Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
7 Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
8 Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding Author: Seyed Saman Talebi (MD), Email: samantalebi@gmail.com

Abstract

Background: Hypertension and diabetes are common comorbidities in patients with COVID-19 and could be influencing the mortality of such patients. The present study aimed to evaluate the effects of hypertension alone and in comorbidity with diabetes on the death within 30 days among inpatients with COVID-19 in presence of well-known determinates of COVID-19 death.

Study Design: A case-control study.

Methods: Four groups of COVID-19 inpatients including controls, diabetes alone, hypertension alone, and hypertension and diabetes comorbidities were defined. Each study groups did not have underlying diseases other than hypertension and diabetes. Demographic and general characteristics, underlying diseases, and hospital course events were extracted from medical records. The outcome of interest was alive at discharge/ death within 30 days after admission. Multivariable binary logistic analysis was employed to estimate the effect measures.

Results: The number of death within 30 days among controls (n=1359), diabetes alone (159), hypertension alone (406) and hypertension and diabetes comorbidities (188) were 12.68%, 15.72%, 20.74% and 26.74%, respectively. According to three multivariable analyses after adjusting older age, hospital length of stay, and intensive care unit (ICU) admission separately, the odds of death within 30 days in COVID-19 patients with having hypertension and diabetes comorbidities was 1.58, 2.13 and 1.91 times of patients without such comorbidities, respectively (P<0.015). The effect of hypertension alone was also significant after adjusting hospital length of stay and ICU admission but not for older age.

Conclusion: Our results suggest that comorbidities, such as hypertension and diabetes may be associated with COVID-19-related deaths independent of other underlying diseases, older age, and adverse hospital course events.


Please cite this article as follows: Ayubi E, Torkaman Asadi F, Borzouei S, Alafchi B, Faghih Soleimani M, Khosronejad S, et al. Effects of hypertension alone and in comorbidity with diabetes on death within 30 days among inpatients with COVID-19 infection. J Res Health Sci. 2022; 22(4):e00565. doi:10.34172/jrhs.2022.100
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PDF Download: 283

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Full Text View: 196

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Submitted: 09 Oct 2022
Revision: 15 Nov 2022
Accepted: 07 Dec 2022
ePublished: 29 Dec 2022
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