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J Res Health Sci. 2025;25(3): e00658.
doi: 10.34172/jrhs.7768
  Abstract View: 60
  PDF Download: 31

Original Article

Diagnostic Value of Fine Needle Aspiration in Diagnosis of Thyroid Nodules at the Endocrine Clinic of Hamadan City During a 10-Year Period, Iran

Mahsa Zamiri Mofid 1 ORCID logo, Erfan Ayubi 2 ORCID logo, Aidin Tarokhian 1, Shiva Borzouei 3* ORCID logo

1 Department of Medicine, Faculty of Medicine, Hamadan University Medical Sciences, Hamadan, Iran.
2 Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Endocrinology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding Author: Shiva Borzouei, Email: borzooeishiva@yahoo.com

Abstract

Background: Thyroid nodules are common endocrine disorders. Most nodules are benign, with only 5% to 15% being malignant. Fine needle aspiration (FNA) is a primary diagnostic method; however, recent studies have raised concerns about its diagnostic reliability. This study aimed to evaluate performance of FNA in diagnosing thyroid nodules using pathology results as the gold standard.

Study Design: A cross-sectional study.

Methods: This study analyzed patients who were referred to an endocrine clinic in Hamadan city and underwent thyroidectomy during a 10-year period. The collected data included demographics, clinical symptoms, FNA results, and pathological outcomes. Statistical analysis was conducted using Stata software, with the significance level set at 0.05.

Results: The study included 700 patients, predominantly female (86.2%), with a mean age of 42.5 years. FNA results were as follows: non-diagnostic in 4.8% (n=43), benign in 43.4% (n=304), atypia of undetermined significance or follicular lesion of undetermined significance in 6.1% (n=42), follicular neoplasm in 13.2% (n=92), suspicious for malignancy in 22.8% (n=160), and malignant nodules in 9.7% (n=68) of the cases. Pathology revealed malignant nodules in 56.9% (n=398) of the cases, predominantly papillary carcinoma. Significant factors associated with malignancy included younger age, male gender, history of thyroid cancer in a first-degree relative, and the presence of cervical adenopathy. FNA showed a sensitivity of 72.43% (95% CI 67.58%, 76.93%) and a specificity of 89.64% (95% CI 85.46%, 92.95%), with an accuracy of 79.85% (95% CI 76.55%, 82.87%).

Conclusion: While FNA is a valuable diagnostic tool for thyroid nodules, its sensitivity varies, necessitating close follow-up of patients with negative results.



Please cite this article as follows: Zamiri Mofid M, Ayubi E, Tarokhian A, Borzouei S. Diagnostic value of fine needle aspiration in diagnosis of thyroid nodules at the endocrine clinic of Hamadan city during a 10-year period, Iran. J Res Health Sci. 2025; 25(3):e00658. doi:10.34172/jrhs.7768
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Submitted: 08 Nov 2024
Revision: 07 Dec 2024
Accepted: 28 Feb 2025
ePublished: 10 Jun 2025
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