Hamadan University of Medical Sciences Journal of Research in Health Sciences 2228-7795 26 2 2026 02 21 Predictors of In-Hospital Mortality Among Stroke Patients in Mashhad, Iran: A Novel Circular Approach to Incorporate Spatial Component e00678 e00678 10.34172/jrhs.11685 EN Nooshin Akbari Sharak https://orcid.org/0000-0003-0972-0023 Morteza Najibi Mohammad Taghi Shakeri https://orcid.org/0000-0002-8287-9594 Journal Article 10.34172/jrhs.11685 2025 10 13 2025 12 16 Background: Stroke remains a global health challenge, with its burden disproportionately affecting developing nations, including Iran. Rapid access to medical care is crucial for improving outcomes. However, spatial and temporal factors often leads to delays, adversely impacting survival. This study investigated predictors of in-hospital mortality among stroke patients in Mashhad, Iran, with a novel focus on spatial directionality using circular statistical methods. Study Design: A retrospective cohort study. Methods: The data of 1,171 stroke patients transported to Ghaem Hospital (2018–2019) were analyzed in this study. Pre-hospital delays, demographics, and clinical factors were assessed alongside spatial directionality, represented by the bearing angle between patients’ residences and the hospital. Circular logistic regression was used to model in-hospital mortality, incorporating both linear and circular predictors. Results: The in-hospital mortality rate was 14.3%. Independent predictors included age (OR: 1.03, 95% CI: 1.01–1.04), length of stay (OR: 1.02, 95% CI: 1.01–1.04), triage level (OR: 2.31, 95% CI: 1.20–4.45), ambulance accessibility (OR: 0.97, 95% CI: 0.96–0.99), and the sine of the bearing angle (OR: 1.37, 95% CI: 1.02–1.83). Mortality was higher along the north-south axis, potentially reflecting disparities in healthcare access and population characteristics. Gender and final diagnosis were not significant predictors. Conclusion: Overall, age, length of stay, triage level, ambulance accessibility, and spatial directionality were significant predictors of in-hospital stroke mortality. The circular statistical approach provided added value by detecting directional disparities not captured through conventional methods, underscoring the need for spatially informed interventions to reduce inequities in stroke outcomes.