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J Res Health Sci. 2024;24(1): e00601.
doi: 10.34172/jrhs.2024.136
  Abstract View: 94
  PDF Download: 52

Original Article

Rifampicin Resistant Tuberculosis Among Presumptive Pulmonary Tuberculosis in Province Referral Hospital, Indonesia: Dynamic Cases of a 7-Year Report

Novi Maulina 1* ORCID logo, Zinatul Hayati 1, Kartini Hasballah 2, Zulkarnain Zulkarnain 3, Ika Waraztuty 4, Azzaura Defadheandra 4

1 Microbiology Department, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, 23116, Indonesia
2 Pharmacology Department, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, 23116, Indonesia
3 Physiology Department, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, 23116, Indonesia
4 Anatomy Department, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, 23116, Indonesia
*Corresponding Author: Novi Maulina, Email: novimaulina@usk.ac.id

Abstract

Background: Indonesia has the second highest tuberculosis (TB) cases globally. This study aimed to determine the sociodemographic factors associated with TB and rifampicin-resistant tuberculosis (RR-TB) cases among presumptive pulmonary TB patients in Aceh Referral Hospital.

Study Design: A retrospective cross-sectional study.

Methods: A retrospective cross-sectional review of presumptive pulmonary TB patients having a sputum test at the clinical microbiology laboratory was conducted from January 2015 to December 2021. Patient characteristics and drug susceptibility data were abstracted from the hospital information system of TB (SITB) and analyzed by univariate and bivariate analysis.

Results: The Mycobacterium tuberculosis (MTB) was detected in 32.8% sample (1,521/4,637). Of the TB-confirmed cases, 14.1% (215/1,521) were resistant to rifampicin (RR-TB). Most of them were male patients (71.63%), were in the age range of 35–54 years (48.7%), lived in rural areas of the country (56.3%), and were previously TB-treated cases (65.5%). Overall, 35–44-year-old patients (adjusted odds ratio [AOR]=2.11, 95% CI=1.25, 3.5, P<0.05) were more likely to have RR-TB compared to>65-year-old patients. Gender and residence were not associated with RR-TB (P>0.05). Case detection decreased in pandemic conditions (19.5% in 2019 to 13.9% and 7.91% in 2020 and 2021, respectively).

Conclusion: The findings revealed the dynamic cases and sociodemographic factors of TB and RR-TB in a province referral hospital in Indonesia for 7 years. The cases of TB and RR-TB among presumptive TB patients were 32.8% and 14.1%, respectively. The cases were found to be more noticeable in males, adults (45–54 years old), and patients residing in rural areas.


Please cite this article as follows: Maulina N, Hayati Z, Hasballah K, Zulkarnain Z, Waraztuty I, Defadheandra A. Rifampicin resistant tuberculosis among presumptive pulmonary Tuberculosis in province referral hospital, Indonesia: dynamic cases of a 7-year report. J Res Health Sci. 2024; 24(1):e00601. doi:10.34172/jrhs.2024.136
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Submitted: 26 Dec 2023
Revision: 14 Jan 2024
Accepted: 20 Feb 2024
ePublished: 15 Mar 2024
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